Publications

Normand C, Breton B, Salze M, Barbeau E, Mancini A, Audet M, July 2022, A systematic analysis of prostaglandin E2 type 3 receptor isoform signaling reveals isoform- and species-dependant L798106 Gαz-biased agonist responses, European Journal of Pharmacology, 927:175043.


Audet M*, Villers K, Velasquez J, Chu M, Hanson C, Stevens RC*, January 2020, Small-scale approach for pre-crystallization screening in GPCR X-Ray crystallography, Nature protocols, 15(1):144-160.*corresponding authors


Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Wenqing S, Katritch V, Cherezov V, Hanson MA, Stevens RC, January 2019, Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor, Nature Chemical Biology, 15(1):11-17.


Audet M, Stevens RC, February 2019, Emerging structural biology of lipid G protein-coupled receptors, Protein Science, 28(2):292-304.


Eddy MT, Lee MY, Gao ZG, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wüthrich K, January 2018, Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor, Cell, 172(1-2):68-80.


Schönegge AM, Gallion J, Picard LP, Wilkins AD, Le Gouill C, Audet M, Stallaert W, Lohse MJ, Kimmel M, Lichtarge O, Bouvier M. December 2017, Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity, Nature Communications, 8:2169.


Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M. April 2017, A new inhibitor of the β-arrestin/AP-2 endocytic complex reveals interplay between GPCR internalization and signalling, Nature Communications, 8:15054.


Audet M, Bouvier M, September 2012, Restructuring G Protein-Coupled Receptor Activation, Cell, 151(1):14-23.


Stallaert W, Dorn JF, van der Westhuizen E, Audet M, Bouvier M, January 2012, Impedance responses reveal β2-adrenergic receptor signaling pluridimentionality and allow classification of ligands with distinct signaling profiles, Plos One (IF: 2.776), 7(1): e29420.


Audet M, Lagace M, Silversides DW, Bouvier M, August 2010, Protein-Protein Interactions Monitored in Cells from Transgenic Mice Using Bioluminescence Resonance Energy Transfer, FASEB J, 24(8), 2829-38.


Audet M, Bouvier M, July 2008, Insights into signaling from the β2-adrenergic receptor structure, Nature Chemical Biology, 4(7), 397-403.


Coulon V, Audet M, Homburger V, Bockaert J, Fagni L, Bouvier M, Perroy J, February 2008, Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer, Biophysical Journal, 94(3):1001-1009.


Galés C, Van Durm JJ, Schaak S, Pontier S, Percherancier Y, Audet M, Paris H, Bouvier M, September 2006, Probing the activation-promoted structural rearrangements in preassembled receptor-G-protein complexes, Nature Structural and Molecular Biology, 13(9), 778-786.



Hamdan FF, Audet M, Garneau P, Pelletier J, Bouvier M, August 2005, High-throughput screening of G protein-coupled receptors antagonists using a BRET1-based β-arrestin2 recruitment assay, Journal of Biomolecular Screening, 10(5), 463-475.